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Converting a CAD Model into a Manufacturing Model for the Components Made of a Multiphase Perfect Material
To manufacture the component made of a multiphase perfect material (including homogeneous
and multi heterogeneous materials), it CAD model should be processed and converted into
layered manufacturing model for further transformation of numerical control (NC) coding. This
paper develops its detailed approaches and corresponding software. The process planning is made
first and includes: (1) determining the build orientation of the component; and (2) slicing the
component into layers adaptively according to different material regions since different materials
have different optimal layer thickness for manufacturing. After the process planning, the layered
manufacturing models with necessary information, including fabrication sequence and material
information of each layer, are fully generated.Mechanical Engineerin
Circulating Cell-Free DNA
Circulating cell-free DNA (cfDNA) refers to extracellular DNA present in body fluid that may be derived from both normal and diseased cells. The concentration, integrity, genetic, and epigenetic alternations in the cfDNA may suggest pathological conditions of the body, such as inflammation, autoimmune diseases, stress, or even malignancies. cfDNA from patients with malignancies contains variants as those in the tumor tissue cells, thus allowing noninvasive assessment of tumor in real time. The clinical detection of cfDNA is one major application of liquid biopsy and has great application value in the early diagnosis of clinical tumors, real-time progression monitoring, curative effect observation and evaluation, prognosis assessment, and metastasis risk analysis. This chapter summarizes the origin of cell-free DNA and its important clinical applications as a noninvasive biomarker
First-Principles Investigation of Anistropic Hole Mobilities in Organic Semiconductors
We report a simple first-principles-based simulation model (combining quantum mechanics with Marcus−Hush theory) that provides the quantitative structural relationships between angular resolution anisotropic hole mobility and molecular structures and packing. We validate that this model correctly predicts the anisotropic hole mobilities of ruberene, pentacene, tetracene, 5,11-dichlorotetracene (DCT), and hexathiapentacene (HTP), leading to results in good agreement with experiment
Unidirectional anisotropy in cubic FeGe with antisymmetric spin-spin-coupling
We report strong unidirectional anisotropy in bulk polycrystalline B20 FeGe
measured by ferromagnetic resonance spectroscopy. Bulk and micron-sized samples
were produced and analytically characterized. FeGe is a B20 compound with
inherent Dzyaloshinskii-Moriya interaction. Lorenz microscopy confirms a
skyrmion lattice at in a magnetic field of 150 mT.
Ferromagnetic resonance was measured at ,
near the Curie temperature. Two resonance modes were observed, both exhibit a
unidirectional anisotropy of in
the primary, and in the secondary
mode, previously unknown in bulk ferromagnets. Additionally, about 25 standing
spin wave modes are observed inside a micron-sized FeGe wedge, measured at room
temperature ( K). These modes also exhibit unidirectional
anisotropy
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